解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:This study aimed to investigate baseline data on malaria before the evaluation of new vector control strategies in an area of pyrethroid-resistance of vectors. The burden of malaria was estimated in terms of infection (prevalence and parasite density) and of clinical episodes. METHODS:Between December 2007 ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-380
更新日期:2010-12-31 00:00:00
abstract:BACKGROUND:In south-eastern Senegal, malaria and onchocerciasis are co-endemic. Onchocerciasis in this region has been controlled by once or twice yearly mass drug administration (MDA) with ivermectin (IVM) for over fifteen years. Since laboratory-raised Anopheles gambiae s.s. are susceptible to ivermectin at concentra...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-365
更新日期:2010-12-20 00:00:00
abstract:BACKGROUND:Intravenous injection of mice with attenuated Plasmodium berghei sporozoites induces sterile immunity to challenge with viable sporozoites. Non-intravenous routes have been reported to yield poor immunity. Because intravenous immunization has been considered to be unacceptable for large scale vaccination of ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-362
更新日期:2010-12-15 00:00:00
abstract:BACKGROUND:The successful control of insect disease vectors relies on a thorough understanding of their ecology and behaviour. However, knowledge of the ecology of many human disease vectors lags behind that of agricultural pests. This is partially due to the paucity of experimental tools for investigating their ecolog...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-356
更新日期:2010-12-08 00:00:00
abstract:BACKGROUND:Malaria is a leading global cause of preventable morbidity and mortality, especially in sub-Saharan Africa, despite recent advances in treatment and prevention technologies. Scale-up and wide distribution of long-lasting insecticide-treated nets (LLINs) could rapidly decrease malarial disease in endemic area...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-345
更新日期:2010-11-30 00:00:00
abstract:BACKGROUND:Widespread resistance of the main malaria vector Anopheles gambiae to pyrethroids reported in many African countries and operational drawbacks to current IRS methods suggest the convenience of exploring new products and approaches for vector control. Insecticide paint Inesfly 5A IGR™, containing two organoph...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-341
更新日期:2010-11-25 00:00:00
abstract:BACKGROUND:Combination treatments, preferably containing an artemisinin derivative, are recommended to improve efficacy and prevent Plasmodium falciparum drug resistance. Artemether-lumefantrine (AL) and artesunate-amodiaquine (AA) are efficacious regimens that have been widely adopted in sub-Saharan Africa. However, m...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-9-335
更新日期:2010-11-22 00:00:00
abstract:BACKGROUND:Long-lasting insecticidal nets are an effective tool for malaria prevention, and "universal coverage" with such nets is increasingly the goal of national malaria control programmes. However, national level campaigns in several countries have run out of nets in the course of distribution, indicating a problem...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-330
更新日期:2010-11-18 00:00:00
abstract:BACKGROUND:Artemisinin is the current drug of choice for treatment of malaria and a number of other diseases. It is obtained from the annual herb, Artemisia annua and some microbial sources by genetic engineering. There is a great concern that the artemisinin production at current rate will not meet the increasing dema...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-310
更新日期:2010-11-04 00:00:00
abstract::The splenic complications of acute malaria include two different prognostic and treatment entities: splenic infarction and splenic rupture. This is the first case of splenic infarction during an acute malaria due to Plasmodium ovale in a 34-year-old man. As in the majority other described cases of splenic infarction, ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-288
更新日期:2010-10-18 00:00:00
abstract:BACKGROUND:Declining in clinical efficacy of artesunate-mefloquine combination has been documented in areas along the eastern border (Thai-Cambodian) of Thailand. In the present study, the clinical efficacy of the three-day combination regimen of artesunate-mefloquine as first-line treatment for acute uncomplicated fal...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-273
更新日期:2010-10-08 00:00:00
abstract:BACKGROUND:Malaria is endemic in Garo hills of Meghalaya, and death cases are reported annually. Plasmodium falciparum is the major parasite, and is solely responsible for each malaria-attributable death case. Garo hills are categorized high-risk for drug-resistant malaria; however, there exists no data on malaria tran...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-263
更新日期:2010-09-22 00:00:00
abstract:BACKGROUND:Improving the way artemether-lumefantrine (AL) is provided to patients attending clinics is critical to maximize the benefit of this new medicine. In 2007, a new initiative was launched in one part of Kenya to improve malaria case-management through enhanced in-service training and provision of job aids. ME...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-261
更新日期:2010-09-18 00:00:00
abstract:BACKGROUND:Prompt and correct diagnosis of malaria is crucial for accurate epidemiological assessment and better case management, and while the gold standard of light microscopy is often available, it requires both expertise and time. Portable fluorescent microscopy using the CyScope offers a potentially quicker, easie...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-245
更新日期:2010-08-27 00:00:00
abstract:BACKGROUND:The diversity and abundance of Anopheles larvae has significant influence on the resulting adult mosquito population and hence the dynamics of malaria transmission. Studies were conducted to examine larval habitat dynamics and ecological factors affecting survivorship of aquatic stages of malaria vectors in ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-228
更新日期:2010-08-09 00:00:00
abstract:BACKGROUND:The evolution of drug resistance in malaria parasites highlights a need to identify and evaluate strategies that could extend the useful therapeutic life of anti-malarial drugs. Such strategies are deployed to best effect before resistance has emerged, under conditions of great uncertainty. METHODS:Here, th...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-217
更新日期:2010-07-23 00:00:00
abstract::In the 2010 second edition of WHO's guidelines for the treatment of malaria, the relatively new fixed dose combination dihydroartemisinin-piperaquine is included as one of the recommended artemisinin combination therapies. However, experimental testing demonstrates that, due to its intrinsic chemical instability, dihy...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-212
更新日期:2010-07-22 00:00:00
abstract:BACKGROUND:Most malaria rapid diagnostic tests (RDTs) detect Plasmodium falciparum and an antigen common to the four species. Plasmodium vivax-specific RDTs target P. vivax-specific parasite lactate dehydrogenase (Pv-pLDH). Previous observations of false positive Pv-pLDH test lines in P. falciparum samples incited to t...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-198
更新日期:2010-07-10 00:00:00
abstract:BACKGROUND:The relationship between mosquito development and temperature is one of the keys to understanding the current and future dynamics and distribution of vector-borne diseases such as malaria. Many process-based models use mean air temperature to estimate larval development times, and hence adult vector densitie...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-196
更新日期:2010-07-09 00:00:00
abstract:BACKGROUND:Mice with genetic deficiencies in adaptive immunity are used for the grafting of human cells or pathogens, to study human diseases, however, the innate immune responses to xenografts in these mice has received little attention. Using the NOD/SCID Plasmodium falciparum mouse model an analysis of innate defenc...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-197
更新日期:2010-07-09 00:00:00
abstract:BACKGROUND:Development of resistance to different classes of insecticides is a potential threat to malaria control. With the increasing coverage of long-lasting insecticide-treated nets in Tanzania, the continued monitoring of resistance in vector populations is crucial. It may facilitate the development of novel strat...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-193
更新日期:2010-07-07 00:00:00
abstract:BACKGROUND:Health care demand studies help to examine the behaviour of individuals and households during illnesses. Few of existing health care demand studies examine the choice of treatment services for childhood illnesses. Besides, in their analyses, many of the existing studies compare alternative treatment options ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-188
更新日期:2010-06-28 00:00:00
abstract:BACKGROUND:Insecticide-treated nets (ITN) and long-lasting insecticidal treated nets (LLIN) are important means of malaria prevention. Although there is consensus regarding their importance, there is uncertainty as to which delivery strategies are optimal for dispensing these life saving interventions. A targeted mass ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-173
更新日期:2010-06-18 00:00:00
abstract:BACKGROUND:Malaria transmission is complex and is believed to be associated with local climate changes. However, simple attempts to extrapolate malaria incidence rates from averaged regional meteorological conditions have proven unsuccessful. Therefore, the objective of this study was to determine if variations in spec...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-166
更新日期:2010-06-16 00:00:00
abstract:BACKGROUND:Two major cities in West Africa, Accra, the capital of Ghana, and Lagos, the largest city of Nigeria, have significant problems with substandard pharmaceuticals. Both have actively combated the problem in recent years, particularly by screening products on the market using the Global Pharma Health Fund e.V. ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-157
更新日期:2010-06-11 00:00:00
abstract:BACKGROUND:Laboratory studies have demonstrated that a variety of immune signaling pathways regulate malaria parasite infection in Anopheles gambiae, the primary vector species in Africa. METHODS:To begin to understand the importance of these associations under natural conditions, an association mapping approach was a...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-160
更新日期:2010-06-11 00:00:00
abstract:BACKGROUND:The immunological mechanisms responsible for protection against malaria infection vary among Plasmodium species, host species and the developmental stage of parasite, and are poorly understood. A challenge with live parasites is the most relevant approach to testing the efficacy of experimental malaria vacci...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-145
更新日期:2010-05-27 00:00:00
abstract:BACKGROUND:Drug resistance determination for Plasmodium falciparum infections are important to determining the type of treatment to be given. Besides in vivo experiments, molecular methods, such as sequencing and PCR, are now increasingly being used. Here a cheaper alternative to sequencing or the use of multiplex 5'nu...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-134
更新日期:2010-05-21 00:00:00
abstract:BACKGROUND:Individuals in a malaria endemic community differ from one another. Many of these differences, such as heterogeneities in transmission or treatment-seeking behaviour, affect malaria epidemiology. The different kinds of heterogeneity are likely to be correlated. Little is known about their impact on the shape...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-132
更新日期:2010-05-17 00:00:00
abstract:BACKGROUND:Genetically-modified (GM) mosquitoes have been proposed as part of an integrated vector control strategy for malaria control. Public acceptance is essential prior to field trials, particularly since mosquitoes are a vector of human disease and genetically modified organisms (GMOs) face strong scepticism in d...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-128
更新日期:2010-05-14 00:00:00
abstract:BACKGROUND:Prior studies have shown that annual entomological inoculation rates (EIRs) must be reduced to less than one to substantially reduce the prevalence of malaria infection. In this study, EIR values were used to quantify the impact of insecticide-treated bed nets (ITNs), indoor residual spraying (IRS), and sour...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2875-9-122
更新日期:2010-05-12 00:00:00
abstract:BACKGROUND:Malaria is a major public health burden in Southeastern Bangladesh, particularly in the Chittagong Hill Tracts region. Malaria is endemic in 13 districts of Bangladesh and the highest prevalence occurs in Khagrachari (15.47%). METHODS:A risk map was developed and geographic risk factors identified using a B...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-120
更新日期:2010-05-09 00:00:00
abstract:BACKGROUND:Premature death of Plasmodium-infected erythrocytes is considered to favourably influence the clinical course of malaria. Aurothiomalate has previously been shown to trigger erythrocyte death or eryptosis, which is characterized by cell membrane scrambling leading to phosphatidylserine exposure at the cell s...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-118
更新日期:2010-05-07 00:00:00
abstract:BACKGROUND:Malaria continues to be a major public health problem in remote forested areas in Cambodia. As a national strategy to strengthen community-based malaria control, the Cambodian government has been running the Village Malaria Worker (VMW) project since 2001. This study sought to examine the nature and quality ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-109
更新日期:2010-04-23 00:00:00
abstract:BACKGROUND:Chloroquine-resistant Plasmodium falciparum was first described in the Republic of Vanuatu in the early 1980s. In 1991, the Vanuatu Ministry of Health instituted new treatment guidelines for uncomplicated P. falciparum infection consisting of chloroquine/sulphadoxine-pyrimethamine combination therapy. Chloro...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-89
更新日期:2010-04-06 00:00:00
abstract:BACKGROUND:With an Annual Parasite Incidence (API) of 132.1, in the high and moderate risks zones, the Maroni area of French Guiana has the second highest malaria incidence of South-America after Guyana (API = 183.54) and far above Brazil (API = 28.25). Malaria transmission is occurring despite strong medical assistanc...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-80
更新日期:2010-03-22 00:00:00
abstract:BACKGROUND:Azithromycin (AZM) is a macrolide antibiotic that displays an excellent safety profile even in children and pregnant women and has been shown to have anti-malarial activity against blood stage Plasmodium falciparum. This study evaluated the transmission-blocking effect of AZM using a rodent malaria model. M...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-73
更新日期:2010-03-10 00:00:00
abstract:BACKGROUND:Control of the major African malaria vector species continues to rely extensively on the application of residual insecticides through indoor house spraying or bed net impregnation. Insecticide resistance is undermining the sustainability of these control strategies. Alternatives to the currently available co...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-71
更新日期:2010-03-08 00:00:00
abstract:BACKGROUND:Plasmodium falciparum readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competitive drug binding at the enzyme's active site. Analogous mutations can be found in the DHFR gene in...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-65
更新日期:2010-03-02 00:00:00
abstract:BACKGROUND:Previous efforts to eradicate malaria parasites, particularly Plasmodium falciparum, have failed in part due to the emergence of drug resistant parasites and mosquitoes resistant to insecticides. Using an artemisinin-based combination therapy (ACT) that kills parasites quickly, a strategy was designed to eli...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-57
更新日期:2010-02-23 00:00:00